The first irradiator produced by Rad Source was the RS 2000 Biological Research Irradiator. It was designed to replace self-shielded cesium-137 gamma irradiators. It is the most popular X-ray irradiator produced by Rad Source with over 125 units installed world-wide in many renowned hospital, university, and pharmaceutical research institutions. The RS 2000 is used by researchers for the irradiation of cells (cell arrestment) and small animals (myeloablation - chimera creation). The RS 2000 beam profile is the same as the RS 3000 that the FDA declared was "Substantially Equivalent" to cesium-137. It is unique for its "Plug and Play" ease of use.
In 1999, Rad Source developed the first blood X-ray irradiator, the RS 3000, for the irradiation of transfusion blood. Transfusion blood is irradiated to inactivate components that cause Graft-versus-host disease (GVHD). The RS 3000 was extremely important because it was the first X-ray unit the FDA identified as being "substantially equivalent" to cesium-137 irradiation for the purposes of blood irradiation.
In 2003, Rad Source was approached by MDS Nordion for the licensing rights to the RS 3000.
The standard design for an X-ray tube has varied very little from the originals built by Roentgen in 1895.The primary restriction for scaling the amount of ionizing radiation produced by these X-ray tubes was the excessive heat generation resulting in the destruction of the X-ray tube. In 2006, Rad Source overcame this heat restriction design by significantly increasing the target area which allows for the generation of high levels of ionizing radiation while still allowing for adequate cooling. The resulting design is the 4 pi X-ray Emitter. This X-ray tube is featured in the RS 2400 and RS 2500 irradiator series and is capable of generating ionizing doses up to 10 kGy (1 Mrad) per hour.
In 2007, the USDA-ARS approached Rad Source to develop an X-ray irradiator capable of replacing their cobalt-60 gamma irradiator used for the sterilization of male screwworm flies. The USDA raises, sterilizes, and releases millions of screwworm flies each year as part of a program used to control the screwworm flies population. The technique is called sterile insect technique (SIT).