The RS 2000 is the non-isotope alternative to radioactive source equipment for research irradiation applications. This system is powerful and flexible enough to assist with biological studies in cancer, bio-technology and selected institutional work including:
- Human Genome
- Myeloablation
- Stem Cell Research
- Small animal work
- Feeder cell production
The RS 2000 complies with applicable CDRH radiation safety standards under CFR 21 1020.40. This means that there is virtually no external radiation while the unit is in operation.
The RS 2000 has user-variable dose rates up to 6 Gy per minute whereas a gamma irradiator's dose rate is dependent on the isotope used and the remaining curies encapsulated. Rad Source has developed the expertise to produce a dose equivalency to gamma irradiators.
The RS 2000 allows for one cycle irradiation of animals in a standard filtered Allentown Cage, which is provided with the equipment and provides 95% horizontal dose uniformity within the rearing cage using our patented reflective holder: RAD+™ (U.S. Patent #6389099).
The RS 2000 is CE-marked for European distribution. (see the RS 2000 features for more information).
MOUSE HEMATOLOGY, A LABORATORY MANUAL
by Michael P. McGarry, Cheryl A. Protheroe, and James J. Lee, Mayo Clinic Arizona
Mouse Hematology presents a concise review of conventional methods for the preparation, enumeration, and microscopic examination of blood and blood-forming tissues of the laboratory mouse. Along with a short laboratory manual featuring detailed protocols, Mouse Hematology includes a DVD of short video demonstrations of the techniques and a poster of blood cell types for easy identification at the microscope. These rapid, inexpensive assessments can save valuable time and resources essential to the design, development, and interpretation of experiments.
Click here for more information.
Purchase the entire manual from Amazon.com.
HIGH KV FOR SMALL ANIMAL AND CELL RESEARCH??
The question is sometimes asked: "Why we don't offer a 320kV irradiator for lab research?" It is certainly not because we couldn't. After all, Rad Source produces and delivers proprietary machines for applications requiring dose rates in excess of 30 kGy! The answer is simple, our RS 2000 was designed and validated for the Biological Research market's typical applications: small animals, cell, and tissue work. The RS 2000 has been in successful use for over 10 years and acclaimed by research laboratories around the globe. The beam profile (proprietary tube and filtering) of the RS 2000 is "Substantially equivalent to Cesium".
Click HERE for a detailed discussion on the "Considerations in the Use of the RS 2000 X-ray Irradiator for Biological Research (Primarily Small Animal, tissue, and cells) and the fallacy of the High KV spectrum."
- Direct replacement for cesium irradiators
- Patented chamber technology* (RAD+™) for excellent dose uniformity
- Irradiation in a filtered environment (no cross-contamination issues)
- Three filtered cages supplied with each system delivered.
- Programmable techniques using touch panel screen
- Unique shielding design far exceeds U.S. CDRH requirements
- Self-cooled, no water source required
- No NRC licensing or reporting required
- Complete dose mapping
- 12-month warranty
- Currently in use at some of the finest public and private research institutions in the world
- Programmable memory for common techniques.
- Single day plug-and-play installation.
- Mounted on casters for easy delivery, installation, and cleaning.
- Detachable power cord for easy installation - no hardwiring required.
- Adjustable pre-warn delay of 1-199 seconds and two low voltage safety interlocks.
- X-ray control assembly controls kV, mA, exposure time and interlocks.
- Configurable to accommodate most irradiation situations. Variable functions include kV (photon energy), mA (current), source distance, time, and beam filtration.
- Operates from a single power source 208-220 VAC 60Hz (North America) or 380 VAC 50 Hz (EU)
- Radcal Accu-Pro in-chamber real-time dosimeter - optional
- Laser position beam limiting collimator for tumor work - optional
- Extended warranty contracts - optional
Human Interface System
Rad Source utilizes a touch screen human interface system with an intuitive logic tree to easily control and monitor the irradiator. The main control screen leads to a number of branches that warm up the tubes to insure constant output, set output parameters and monitor machine activity such as vacuum, cooling and power consumption. Most important are the programmable features that allow techniques to be used on a routine basis with the touch of a virtual button.
*Patent number 6,389,099
- Is the RS 2000 a direct replacement for a gamma irradiator?
- Yes, x-rays from the RS 2000 produce equivalent dose in cells and small animals. The energy of the photons is lower however, and the x-ray must have correct filtration shaping beam to produce equivalent uniformity.
- How is the RS 2000 similar to gamma irradiator?
- Both use photons as an irradiation source, creating ionizing radiation. The energy of both is energy per unit volume with 1 Gy from Gamma equal to 1 Gy from x-ray.
- How do dose rates compare to a gamma irradiator?
- The dose rate of a gamma irradiator is not variable for irradiation buts decreases over time. The RS 2000 allows the user to vary dose rate electronically or by varying distance but remains constant unless changed by the user.
- What is the dose uniformity of the RS 2000 and how does it compare to a gamma irradiator?
- Each RS 2000 is calibrated at the factory for maximum uniformity and has 95% or better uniformity for an area of 7" x 11" (typical rearing cage) at 1 Gy per minute.
- Do I need a Nuclear Site License or an RSO (Radiation Safety Officer) with the RS 2000?
- NO. The RS 2000 is licensed as a cabinet x-ray system and complies with CFR 21.1020.40.
- Do I need a lead lined room or secure access for the RS 2000
- NO. The RS 2000 is completely self shielded and needs no additional precautions and is key operated for user security. Background scatter is lower than Federal and State guidelines.
- Are there any floor loading or environmental concerns when using the RS 2000?
- NO. The RS 2000 is mounted on wheels and weighs less than 1500 lbs.
- What is the size of the irradiation field?
- The radiation plane is in a cone shaped irradiation field and can be set at various levels from 12.39 cm (4.88") to 35.50cm (13.98").
- How does the cost of an RS 2000 compare to that of a gamma (cesium or cobalt) unit?
- When delivery, licensing and related Hazardous Material shipping and set-up costs of a radioisotope system are considered, the RS 2000 costs much less than a typical gamma unit.
- Are there any down line disposal issues with the RS 2000?
- NO. Unlike a nuclear isotope, the RS 2000 is an electronic device that is either on or off. When it is off it is completely inert. In fact, many gamma system users do not know how, or at what cost, their nuclear system will be able to be disposed of.
- How is the RS 2000 installed?
- The RS 2000 is rolled (its mounted on casters) into your facility and simply plugged in to a dedicated 220VAC single phase 40 amp circuit. Its cooling system is completely self-contained. Installation, calibration, dose mapping and In-service is completed in less than one day.
- How reliable is the RS 2000?
- The RS 2000 consists of a power supply, radiation tube, control module, chassis and heat exchanger. The unit runs at below its components maximum capacity, so no component is being stressed. We offer 1-, 2- and 3-year extended warranty programs. We have units that have been in service for over 5 years with no major service calls.
- What makes the RS 2000 ideal for small animal research?
- The RS 2000 is designed to allow irradiation of mice in a filtered cage. We understand husbandry is an important part of the process so keeping the mice out of the outside environment, especially with multiple users is key.
- What if I need higher dose levels or faster throughput?
- Rad Source produces custom irradiation solutions using our scaleable technology. Click here for more information
X-ray source: 160 kV, 4.2 kW
Timer: Adj. by 10ths of minute
Utility requirements:
USA: 220VAC, 60 Hz, 40 amps
Europe: 380VAC, 3 phase, 50 Hz, 20 amps
Current: Adj. 2 to 25 mA
BTUs: 512 per minute
Cooling: 30 Gals (114L) water
Inside Chamber Dimensions:
Width: 17" (43.2 cm)
Height: 17" (43.2 cm)
Depth: 15" (38.1 cm)
Overall Dimensions:
Width: 42" (106.7 cm)
Height: 72" (182.9 cm)
Depth: 33" (83.8 cm)
Weight:
1250 lbs.
Warranty:
One Year Complete Parts and Labor
Specifications are subject to change without notice
